Abstract: Using the plate confrontation assay, thirteen strains with antagonistic effect on Cylindrocarpon destructans (Zinss.) Scholtan were screened out of 97 bacteria which were isolated from the ginseng rhizosphere soil of Fusong County of Jilin Province in China. The plate-confrontation method and growth speed rate method were used for preliminary screening and antimicrobial test in vitro.Pots trails were carried out to assess the inhibitory activity of strain SZ-22 in vivo. The results showed that the inhibition rate of strain SZ-22 fermentation broth was 82.63% to C. destructans (Zinss.) Scholtan and also had good broad-spectrum antimicrobial effect. The strain SZ-22 had significant control efficacy when compared with the pesticides treatments, the control efficacy of the aseptic filtrate of SZ-22 reached to 63.02% with no dilution, and more than 50% in 10 times dilution in pots trails,respectively.According tomorphologic, physiological and biochemical characteristics and 16S rDNA sequence analysis, strain SZ-22 was classified as Brevundimonas terrae.